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Proteins and Peptides

Human ITPRIPL1 Protein, Fc Tag (MALS verified)

Product Sizes
100 ug
£401.00
IT1-H5253-100UG
1 mg
£2632.00
IT1-H5253-1MG
About this Product
SKU:
IT1-H5253
Buffer:
PBS
Extra Details:
Inositol 1,4,5-triphosphate receptor interacting protein like 1 (ITPRIPL1) is a single transmembrane protein, exhibits normal testis-enriched expression and widespread overexpression in various human cancers. ITPRIPL1 is commonly found in tumors with low PD-L1 expression. ITPRIPL1 acts as a natural ligand for CD3 E Epsilon, evading immune surveillance, leading to decreased T cell activity and promoting tumor growth. Research has shown that inducing stable CD3E-NCK1 binding prevents CD3E-ZAP70 interaction, subsequently inhibiting downstream ERK-NFkB signaling cascade and calcium influx activation.
Immunogen:
ITPRIPL1
Molecular Weight:
35.7 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human ITPRIPL1 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human ITPRIPL1 Protein, Fc Tag (Cat. No. IT1-H5253) at 1 ug/mL (100 uL/well) can bind ITPRIPL1 antibody with a linear range of 0.001-0.125 ug/mL (QC tested).