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Proteins and Peptides

Human Insulin R / CD220 (28-944) Protein, His Tag, low endotoxin (MALS & SPR verified)

Product Sizes
100 ug
£342.00
INR-H52HA-100UG
1 mg
£2438.00
INR-H52HA-1MG
About this Product
SKU:
INR-H52HA
Additional Names:
CD220|INSR|Insulin receptor|IR
Buffer:
PBS
Extra Details:
Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.
Immunogen:
Insulin R
Molecular Weight:
83.6 kDa and 22.8 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
Human Insulin R (28-944), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human Insulin R (28-944), His Tag (Cat. No. INR-H52Ha) at 5 ug/mL (100 uL/well)can bind Human IGF-II, Fc Tag (Cat. No. IG2-H4260) with a linear range of 0.078-2.5 ug/mL (QC tested).
Immobilized Human Insulin R (28-944), His Tag (Cat. No. INR-H52Ha) at 5 ug/mL (100 uL/well)can bind Insulin Biotin Conjugate with a linear range of 0.02-0.313 ug/mL (Routinely tested).