Biotinylated Human IL-1 beta / IL-1F2 Protein, His,Avitag[TM] (MALS verified)
Product Sizes
25 ug
£377.00
ILB-H82E9-25UG
200 ug
£1614.00
ILB-H82E9-200UG
About this Product
- SKU:
- ILB-H82E9
- Additional Names:
- IL-1BETA|IL-1B Beta|IL1B|IL1F2
- Buffer:
- PBS
- Conjugate:
- Biotin
- Extra Details:
- Interleukin-1 beta (IL-1B Beta) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1B Beta precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta. IL1B Beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1A Alpha and IL1B Beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1B Beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
- Immunogen:
- IL-1 beta
- Molecular Weight:
- 21.0 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
