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Proteins and Peptides

Human IL-1 RII / CD121b Protein, His Tag

Product Sizes
100 ug
£289.00
IL2-H4226-100UG
1 mg
£1867.00
IL2-H4226-1MG
About this Product
SKU:
IL2-H4226
Additional Names:
CD121b|CDw121b|IL1R2|IL1RB
Buffer:
PBS
Extra Details:
Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Immunogen:
IL-1 RII
Molecular Weight:
38.9 kda
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human IL-1 RII, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human IL-1 beta, Fc Tag (Cat. No. ILA-H525c) at 5 ug/mL (100 uL/well) can bind Human IL-1 RII, His Tag (Cat. No. IL2-H4226) with a linear range of 1-20 ng/mL (QC tested).