Biotinylated Mouse IL-11 Protein, His,Avitag[TM] (HPLC verified)
Product Sizes
25 ug
£430.00
IL1-M82Q8-25UG
200 ug
£1861.00
IL1-M82Q8-200UG
About this Product
- SKU:
- IL1-M82Q8
- Buffer:
- PBS, 10 mM citric acid, pH5.5
- Conjugate:
- Biotin
- Extra Details:
- IL-11 (Interleukin 11) is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27 and IL-31. In humans, IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF). The human IL-11 cDNA encodes a 199 amino acid (aa) precursor, which generates a 178-aa, 19-kDa mature unglycosylated protein. Mature human IL-11 shares 88%, 88%, and 96% aa sequence identity with mouse, rat and canine IL-11, respectively. IL-11 is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts, among other cell types. It is found in the plasma mainly during inflammation, such as that associated with viral infection, cancer, or inflammatory arthritis, and is traditionally considered primarily anti-inflammatory. It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine. It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone resorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis. IL-11 synergizes with several other cytokines to produce these effects, and its effects overlap with those of IL-6. IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11RA Alpha and two molecules of the ubiquitously expressed signaling subunit gp130. A soluble form of IL-11RA Alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface, or inhibit signaling mediated by the cell-surface IL-11RA Alpha/gp130 complex.
- Immunogen:
- IL-11
- Molecular Weight:
- 22.9 kda
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
