Biotinylated Human IGF-I R / IGF-1 R Protein, His,Avitag[TM] (MALS verified)
Product Sizes
25 ug
£430.00
IGR-H83E3-25UG
200 ug
£1861.00
IGR-H83E3-200UG
About this Product
- SKU:
- IGR-H83E3
- Buffer:
- PBS
- Conjugate:
- Biotin
- Extra Details:
- The Insulin-like Growth Factor 1 Receptor (IGF1R) is also known as CD221 and JTK13, and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide hormone similar in molecular structure to insulin. IGF1R is made up of two A Alpha subunits and two B Beta subunits. Both the A Alpha and B Beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by disulfide bonds to form a functional transmembrane A AlphaB Beta chain. The A Alpha chains are located extracellularly, while the B Beta subunits span the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R has a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is 60% sequence homology between IGF1R and the insulin receptor. In response to ligand binding, the A Alpha chains induce the tyrosine autophosphorylation of the B Beta chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.
- Immunogen:
- IGF-I R / IGF-1 R
- Molecular Weight:
- 106.4 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
