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Proteins and Peptides

Human IGF-I R / IGF-1 R Protein, Fc Tag

Product Sizes
100 ug
£413.00
IGR-H5253-100UG
1 mg
£2585.00
IGR-H5253-1MG
About this Product
SKU:
IGR-H5253
Buffer:
PBS
Extra Details:
The Insulin-like Growth Factor 1 Receptor (IGF1R) is also known as CD221 and JTK13, and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide hormone similar in molecular structure to insulin. IGF1R is made up of two A Alpha subunits and two B Beta subunits. Both the A Alpha and B Beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by disulfide bonds to form a functional transmembrane A AlphaB Beta chain. The A Alpha chains are located extracellularly, while the B Beta subunits span the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R has a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is 60% sequence homology between IGF1R and the insulin receptor. In response to ligand binding, the A Alpha chains induce the tyrosine autophosphorylation of the B Beta chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.
Immunogen:
IGF-I R / IGF-1 R
Molecular Weight:
129.3 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human IGF-I R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human IGF-I R, Fc Tag (Cat. No. IGR-H5253) at 5 ug/mL (100 uL/well) can bind Biotinylated Human IGF-I, Avitag,Fc Tag (Cat. No. IG1-H82F7) with a linear range of 0.01-0.625 ug/mL (QC tested).
Immobilized Human IGF-I R, Fc Tag (Cat. No. IGR-H5253) at 5 ug/mL (100 uL/well) can bind Biotinylated Human IGF-I, His,Avitag (Cat. No. IG1-H82Q6) with a linear range of 10-78 ng/mL (Routinely tested).