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Proteins and Peptides

Human IGFBP-3 Protein, His Tag

Product Sizes
100 ug
£377.00
IG3-H52H9-100UG
1 mg
£1761.00
IG3-H52H9-1MG
About this Product
SKU:
IG3-H52H9
Additional Names:
BP-53|IBP3|IGFBP3
Buffer:
PBS
Extra Details:
Insulin-like growth factor-binding protein 3 is also known as IGFBP3, is a protein that, in humans, is encoded by the IGFBP3 gene. IGFBP3 forms a ternary complex of about 140 ~150 kDa with IGF1 or IGF2 and a glycoprotein insulin-like growth factor acid-labile subunit (ALS), thus alter the interaction of IGFs with their cell surface receptors. IGFBP3 exerts either proapoptotic or growth stimulatory effects depending upon the cellular context. Studies have shown that IGFBP3 can leads to the induction of apoptosis dependent or independent of the IGF-IGF receptor axis, accordingly acts as a negative regulator of tumorigenesis and progressing in certain carcinomas. The highest expression level is found in the nonparanchymal cells of the liver. Expression levels are also higher during extrauterine life and peak during puberty.
Immunogen:
IGFBP-3
Molecular Weight:
30.6 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human IGFBP-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Biotinylated Human IGF-II, Avitag,Fc Tag (Cat. No. IG2-H82F9) at 2 ug/mL (100 uL/well) on streptavidin (Cat. No. STN-N5116) precoated (1 ug/well) plate can bind Human IGFBP-3, His Tag (Cat. No. IG3-H52H9) with a linear range of 0.01-0.313 ug/mL (QC tested).
Immobilized Human IGFBP-3, His Tag (Cat. No. IG3-H52H9) at 5 ug/mL (100 uL/well) can bind Human IGF-I, Fc Tag with a linear range of 0.6-39 ng/mL (Routinely tested).