Human IDH1 (R132C) Protein, His Tag (MALS verified)
Product Sizes
20 ug
£972.00
ID1-H51H8-20UG
100 ug
£1637.00
ID1-H51H8-100UG
500 ug
£4316.00
ID1-H51H8-500UG
About this Product
- SKU:
- ID1-H51H8
- Additional Names:
- IDH1|IDP|PICD
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH7.5
- Extra Details:
- The IDH enzymes catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (A Alpha-KG), producing nicotinamide adenine dinucleotide phosphate (NADPH) in the process via the citric acid cycle. Eukaryotic cells express two distinct classes of IDHs that utilize either NAD or NADP as their cofactors and serve diverse biological functions. NAD-dependent IDH is localized to the mitochondrial matrix and is well known for its central role for energy production in the Krebs cycle. NADP-dependent IDHs are primarily located either in mitochondria or cytoplasm . Each NADP-dependent isozyme is a homodimer. Mutations of Arg132 of human IDH1 result in a reduced ability of the enzyme to convert isocitrate to alpha -ketoglutarate, but the enzyme acquires the ability to generate 2-hydroxyglutarate (2HG) from alpha-ketoglutarate, 2-HG is elevated in several tumor types, including a subset of AMLs.
- Immunogen:
- IDH1
- Molecular Weight:
- 48.5 kDa
- Physical State:
- Liquid
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
