Human HVEM / TNFRSF14 Protein, Fc Tag (MALS verified)
Product Sizes
100 ug
£306.00
HVM-H5258-100UG
1 mg
£2,248.00
HVM-H5258-1MG
About this Product
- SKU:
- HVM-H5258
- Additional Names:
- ATAR|CD270|HVEA|HVEM|LIGHTR|TNFRSF14|TR2
- Buffer:
- Tris with Glycine, Arginine and NaCl, pH7.5
- Extra Details:
- Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFB Beta (lymphotoxin A Alpha) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTB BetaR, the receptor for lymphotoxin A AlphaB Beta heterotrimer. The role of the HVEM LIGHT /LTB Beta receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
- Molecular Weight:
- 43.5 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins