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Biotinylated Human HLA-DRA1*01:01&HLA-DRB1*15:01&MBP (ENPVVHFFKNIVTPR) Complex Protein (Monomer, MALS verified)

Product Sizes
25 ug
£180.00
HLM-H82EA-25UG
200 ug
£707.00
HLM-H82EA-200UG
About this Product
SKU:
HLM-H82EA
Buffer:
PBS
Conjugate:
Biotin
Extra Details:
The peptide ENPVVHFFKNIVTPR, derived from myelin basic protein (MBP), is presented by the MHC class II heterodimer HLA-DRA1*01:01/HLA-DRB1*15:01. This specific peptide-MHC II complex is a predominant autoantigen target in multiple sclerosis (MS) and is strongly associated with the HLA-DRB1*15:01 genetic risk allele. Its recognition by autoreactive CD4⁺ T helper cells initiates and drives the inflammatory immune response against the myelin sheath in the central nervous system, making it a prototypical complex for studying autoimmune demyelination and MS pathogenesis.
Immunogen:
HLA-DRA1*0101 & HLA-DRB1*1501 & MBP(ENPVVHFFKNIVTPR)
Molecular Weight:
29.8 kDa and 29.2 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
Biotinylated Human HLA-DRA1*01:01&HLA-DRB1*15:01&MBP (ENPVVHFFKNIVTPR) Complex Protein on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Biotinylated Human HLA-DRA1*01:01&HLA-DRB1*15:01&MBP (ENPVVHFFKNIVTPR) Complex Protein (Cat. No. HLM-H82Ea) at 1 ug/mL (100 uL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 ug/well) plate can bind Anti-HLA-DR Antibody, Human IgG1 with a linear range of 0.06-2 ng/mL (QC tested).
Immobilized Anti-HLA-DR Antibody, Human IgG1 at 1 ug/mL (100 uL/well) can bind Biotinylated Human HLA-DRA1*01:01&HLA-DRB1*15:01&MBP (ENPVVHFFKNIVTPR) Complex Protein (Cat. No. HLM-H82Ea) with a linear range of 0.5-16 ng/mL (Routinely tested).