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PE-Labeled Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Tetramer Protein

Product Sizes
25 ug
£174.00
HLE-HP2E3-25UG
200 ug
£701.00
HLE-HP2E3-200UG
About this Product
SKU:
HLE-HP2E3
Buffer:
PBS, 1% BSA, 50-150 mM NaCl
Conjugate:
R-PE
Extra Details:
PRAME (Preferentially Expressed Antigen in Melanoma) is a well-characterized member of the cancer/testis antigen family. Functioning as a nuclear receptor and transcriptional regulator, PRAME negatively modulates retinoic acid signaling, thereby regulating tumor cell differentiation and proliferation. It is aberrantly overexpressed in a variety of malignancies, especially cutaneous melanoma, and its upregulation is closely linked to aggressive tumor phenotypes. Given its tumor-specific expression and oncogenic role, PRAME has emerged as a promising diagnostic biomarker, prognostic indicator, and attractive therapeutic target for tumor immunotherapy.
Immunogen:
HLA-A*0201 & B2M & PRAME (ALYVDSLFFL)
Molecular Weight:
36.3 kDa and 11.7 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
Please refer to datasheet
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
Immobilized PE-Labeled Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Tetramer Protein (Cat. No. HLE-HP2E3) at 1 ug/mL (100 uL/well) can bind Monoclonal Anti-HLA class I Antibody, Human IgG1 (W632) with a linear range of 0.03-2 ng/mL (QC tested).
Immobilized PE-Labeled Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Tetramer Protein (Cat. No. HLE-HP2E3) at 1 ug/mL (100 uL/well) can bind Monoclonal Anti-B2M Antibody, Human IgG1 with a linear range of 0.03-2 ng/mL (QC tested).