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Biotinylated Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Complex Protein (Monomer, MALS verified)

Product Sizes
25 ug
£185.00
HLE-H82E6-25UG
200 ug
£731.00
HLE-H82E6-200UG
About this Product
SKU:
HLE-H82E6
Buffer:
PBS
Conjugate:
Biotin
Extra Details:
PRAME (Preferentially Expressed Antigen in Melanoma) is a well-characterized member of the cancer/testis antigen family. Functioning as a nuclear receptor and transcriptional regulator, PRAME negatively modulates retinoic acid signaling, thereby regulating tumor cell differentiation and proliferation. It is aberrantly overexpressed in a variety of malignancies, especially cutaneous melanoma, and its upregulation is closely linked to aggressive tumor phenotypes. Given its tumor-specific expression and oncogenic role, PRAME has emerged as a promising diagnostic biomarker, prognostic indicator, and attractive therapeutic target for tumor immunotherapy.
Immunogen:
HLA-A*0201 & B2M & PRAME (ALYVDSLFFL)
Molecular Weight:
36.3 kDa and 11.7 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
Biotinylated Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Complex Protein on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Biotinylated Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Complex Protein (Cat. No. HLE-H82E6) at 1 ug/mL (100 uL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 ug/well) plate can bind Anti-HLA class I Antibody, Human IgG1 (W6/32) with a linear range of 0.1-2 ng/mL (QC tested).
Immobilized Biotinylated Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Complex Protein (Cat. No. HLE-H82E6) at 1 ug/mL (100 uL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 ug/well) plate can bind Anti-PRAME (ALYVDSLFFL) TCR-Like Antibody (Pr20), HLA-A*0201-Restricted with a linear range of 0.1-2 ng/mL (QC tested).