APC-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His Tag (Site-specific conjugation)
Product Sizes
25 tests
£342.00
GUC-HA2H4-25TESTS
200 tests
£2,142.00
GUC-HA2H4-200TESTS
About this Product
- SKU:
- GUC-HA2H4
- Buffer:
- PBS, 0.5% BSA, pH7.4
- Extra Details:
- GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles. Protect from light.
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes