Human Gremlin / GREM1 Protein, Fc Tag
Product Sizes
100 ug
£330.00
GR1-H5254-100UG
1 mg
£2461.00
GR1-H5254-1MG
About this Product
- SKU:
- GR1-H5254
- Additional Names:
- CKTSF1B1|DAND2|DRM|GREM1|PIG2
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH7.5
- Extra Details:
- Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
- Immunogen:
- Gremlin
- Molecular Weight:
- 44.2 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
