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Proteins and Peptides

Rhesus macaque Glypican 2 / GPC2 Protein, His Tag

Product Sizes
100 ug
£377.00
GP2-R52H9-100UG
1 mg
£2703.00
GP2-R52H9-1MG
About this Product
SKU:
GP2-R52H9
Additional Names:
Glypican 2|GPC2
Buffer:
PBS
Extra Details:
Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/B Beta-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
Immunogen:
Glypican 2
Molecular Weight:
59.9 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Rhesus macaque Glypican 2, His Tag on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Recombinant Human Midkine Protein at 2 ug/mL (100 uL/well) can bind Rhesus macaque Glypican 2, His Tag (Cat. No. GP2-R52H9) with a linear range of 2-31 ng/mL (QC tested).