HIV-1 (HXB2) GP41 Pre-hairpin intermediate Protein, His Tag
Product Sizes
50 ug
£1066.00
GP1-H51H3-50UG
500 ug
£3580.00
GP1-H51H3-500UG
About this Product
- SKU:
- GP1-H51H3
- Buffer:
- 50 mM HEPES, 150 mM NaCl, CHS, pH7.5
- Extra Details:
- Infection by HIV-1 involves the fusion of viral and cellular membranes with subsequent transfer of viral genetic material into the cell. The HIV-1 envelope glycoprotein that mediates fusion consists of the surface subunit gp120 and the transmembrane subunit gp41. gp120 directs virion attachment to the cell-surface receptors, and gp41 then promotes viral-cell membrane fusion. A soluble, alpha-helical, trimeric complex within gp41 composed of N-terminal and C-terminal extraviral segments has been proposed to represent the core of th e fusion-active conformation of the HIV-1 envelope. Three N-terminal helices within the bundle form a central, parallel, trimeric coiled coil, whereas three C-terminal helices pack in the reverse direction into three hydrophobic grooves on the surface of the N-terminal trimer. This thermostable subdomain displays the salient features of the core structure of the isolated gp41 subunit and thus provides a possible target for therapeutics designed selectively to block HIV-1 entry.
- Immunogen:
- Envelope glycoprotein gp41/gp41 (HIV)
- Molecular Weight:
- 44.3 kDa
- Physical State:
- Liquid
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
