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Proteins and Peptides

Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free

Product Sizes
100 ug
£377.00
GA1-C52W7-100UG
1 mg
£2703.00
GA1-C52W7-1MG
About this Product
SKU:
GA1-C52W7
Additional Names:
LRRC32 & TGF-beta 1|LRRC32&TGFB1
Buffer:
PBS
Extra Details:
GARP (LRRC32) is a transmembrane protein that binds latent-TGF-B Beta1 and tethers it on the Treg surface. and has been proved to promote the activation and secretion of transforming growth factor B Beta (TGF-B Beta). The expression of GARP is highly on the surface activated Tregs and increases the suppressive function of Tregs. Additionally, GARP can bind to latent transforming growth factor B Beta (TGF-B Beta), thus promoting secretion and activation of TGF-B Beta. TGF-B Beta plays a critical rule for homeostasis and function of Tregs. Notably, it has been also observed that fibroblasts and endothelial cell lines that express GARP/latent TGF-B Beta1 complexes do not activate TGF-B Beta1. However, it cannot be excluded that specific stimuli are required to trigger TGF-B Beta1 activation from complexes on the surface of these cell types.
Immunogen:
LRRC32 & TGF-beta 1
Molecular Weight:
68.1 kDa (LRRC32) & 41.2 kDa (TGF-beta 1)
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free (Cat. No. GA1-C52W7) at 1 ug/mL (100 uL/well) can bind Biotinylated Human ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT6-H82E4) with a linear range of 1-39 ng/mL (QC tested).