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Proteins and Peptides

Cynomolgus / Rhesus macaque Fas Ligand / TNFSF6 Protein, His Tag, premium grade

Product Sizes
50 ug
£436.00
FAL-H5246-50UG
1 mg
£3627.00
FAL-H5246-1MG
About this Product
SKU:
FAL-H5246
Buffer:
PBS
Extra Details:
Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
Immunogen:
FAS Ligand
Molecular Weight:
18.8 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Cynomolgus / Rhesus macaque Fas Ligand Protein, His Tag, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human Fas Protein, Fc Tag (Cat. No. FAS-H5252) at 5 ug/mL (100 uL/well) can bind Cynomolgus / Rhesus macaque Fas Ligand Protein, His Tag, premium grade (Cat. No. FAL-H5246) with a linear range of 1-31 ng/mL (QC tested).
Immobilized Cynomolgus / Rhesus macaque Fas Ligand Protein, His Tag, premium grade (Cat. No. FAL-H5246) at 2 ug/mL (100 uL/well) can bind Human Fas Protein, Fc Tag (Cat. No. FAS-H5252) with a linear range of 0.1-1 ng/mL (Routinely tested).