PE-Labeled Monoclonal Anti-Human CTLA-4 Antibody, Mouse IgG2a (AS628) (0.03% Proclin)
Product Sizes
200 tests
£277.00
FABM043-01-200TESTS
About this Product
- SKU:
- FABM043-01
- Application:
- Flow Cytometry
- Buffer:
- PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA
- translate.label.attr.clone:
- AS628
- Clonality:
- Monoclonal
- Conjugate:
- R-PE
- Extra Details:
- CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
- Immunogen:
- CTLA-4
- Physical State:
- Liquid
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Protect from light.
- Supplier:
- ACRO Biosystems
- Type:
- Antibody: Monoclonal Antibody
