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Proteins and Peptides

Rat EphA2 Protein, His Tag (MALS verified)

Product Sizes
100 ug
£377.00
EP2-R52H5-100UG
1 mg
£2461.00
EP2-R52H5-1MG
About this Product
SKU:
EP2-R52H5
Buffer:
PBS
Extra Details:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EF1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EF5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EF2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
Immunogen:
EphA2
Molecular Weight:
58.6 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
Rat EphA2 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human Ephrin-A1, Fc Tag (Cat. No. EF1-H5251) at 5 ug/mL (100 uL/well) can bind Rat EphA2 Protein, His Tag (Cat. No. EP2-R52H5) with a linear range of 0.01-0.156 (QC tested).
Immobilized Rat EphA2 Protein, His Tag (Cat. No. EP2-R52H5) at 5 ug/mL (100 uL/well) can bind Human Ephrin-A1, Fc Tag (Cat. No. EF1-H5251) with a linear range of 0.04-1 ng/mL (Routinely tested).