Human E-Cadherin / Cadherin-1 Protein, Fc Tag, premium grade
Product Sizes
100 ug
£271.00
ECD-H5250-100UG
1 mg
£1,812.00
ECD-H5250-1MG
About this Product
- SKU:
- ECD-H5250
- Additional Names:
- Arc-1|Cadherin-1|CD324|CDH1|ECAD|E-cadherin|LCAM|UVO
- Buffer:
- 50 mM Tris, 100 mM Glycine, pH7.5
- Extra Details:
- Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).
- Molecular Weight:
- 92.3 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins