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Proteins and Peptides

Human Dkk-1 Protein, His Tag, premium grade

Product Sizes
20 ug
£185.00
DK1-H5221-20UG
100 ug
£218.00
DK1-H5221-100UG
1 mg
£1349.00
DK1-H5221-1MG
About this Product
SKU:
DK1-H5221
Additional Names:
DKK1|SK
Buffer:
PBS
Extra Details:
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via B Beta-catenin mediated PdgfrA Alpha and E-cadherin expression.
Immunogen:
Dkk-1
Molecular Weight:
26.6 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human Dkk-1 Protein, His Tag, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human Dkk-1 Protein, His Tag, premium grade (Cat. No. DK1-H5221) at 5 ug/mL (100 uL/well) can bind Human LRP-5, Mouse IgG2a Fc Tag (Cat. No. LR5-H5254) with a linear range of 0.01-0.156 ug/mL (QC tested).