Cynomolgus CRTAM Protein, Fc Tag
Product Sizes
100 ug
£324.00
CRM-C5255-100UG
1 mg
£2214.00
CRM-C5255-1MG
About this Product
- SKU:
- CRM-C5255
- Additional Names:
- CD355|CRTAM
- Buffer:
- Tris with Glycine, Arginine and NaCl, pH7.5
- Extra Details:
- Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.
- Immunogen:
- CRTAM
- Molecular Weight:
- 56.6 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
