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Biotinylated Human Claudin-18.2 Full Length Protein (VLP)

Product Sizes
20 ug
£1237.00
CL2-H82P3-20UG
100 ug
£1867.00
CL2-H82P3-100UG
500 ug
£5046.00
CL2-H82P3-500UG
About this Product
SKU:
CL2-H82P3
Buffer:
PBS, Arginine, pH7.4
Conjugate:
Biotin
Extra Details:
Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Immunogen:
Claudin-18.2
Physical State:
Liquid
Shipping Conditions:
Dry Ice
Storage Conditions:
-70[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
Immobilized Biotinylated Human Claudin-18.2 Full Length Protein (VLP) (Cat. No. CL2-H82P3) at 5 ug/mL (100 uL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 ug/well) plate can bind Anti-Claudin-18.2 antibody with a linear range of 0.05-2 ng/mL (QC tested).
ELISA comparison of biotinylated human Claudin-18.2 (virus-like particles) using anti-Claudin-18.2 antibody shows ACRO (Cat. No. CL2-H82P3) has superior bioactivity to Company K (Routinely tested).