Biotinylated Rhesus macaque CD89 / FCAR Protein, His,Avitag[TM] (MALS verified)
Product Sizes
25 ug
£371.00
CD9-R82E3-25UG
200 ug
£1466.00
CD9-R82E3-200UG
About this Product
- SKU:
- CD9-R82E3
- Buffer:
- PBS
- Conjugate:
- Biotin
- Extra Details:
- CD89 (FcA AlphaRI), encoded by the FCAR gene, is an IgA-specific receptor primarily expressed on myeloid cells (e.g., neutrophils, monocytes/macrophages). It mediates immune defense functions by binding to the Fc region of IgA (with a preference for polymeric forms), facilitating phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and inflammation regulation. Its signaling relies on the ITAM motif of the FcRG Gamma chain, enabling dual immunoregulatory roles in both activation and suppression. Clinically, CD89 is implicated in IgA nephropathy, pathogen immune evasion, and tumor immunity. Targeted therapies, such as the bispecific antibody MOR202, are under development for diseases like multiple myeloma, highlighting its therapeutic potential as a bridge between mucosal and systemic immunity.
- Immunogen:
- CD89
- Molecular Weight:
- 26.9 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
