Biotinylated Human CD6 Protein, His,Avitag[TM] (MALS verified)
Product Sizes
25 ug
£377.00
CD6-H82E3-25UG
200 ug
£1614.00
CD6-H82E3-200UG
About this Product
- SKU:
- CD6-H82E3
- Buffer:
- PBS
- Conjugate:
- Biotin
- Extra Details:
- CD6 is a type 1 transmembrane glycoprotein with three extracellular SRCR domains that functions as a co-stimulatory receptor in T cell activation. Its primary ligand is CD166 (ALCAM), an IgSF member expressed on antigen-presenting cells and other tissues. CD6's long cytoplasmic tail contains tyrosine residues that, upon phosphorylation, recruit signaling molecules like SLP76 and SHP1. The CD6-ALCAM interaction promotes T cell activation and downstream MAPK signaling, influencing proliferation, differentiation, and survival. Importantly, CD6 regulates effector T cell (Teff) activity and trafficking, making it a key checkpoint in autoimmunity. Blocking the CD6-ALCAM pathway selectively inhibits pathogenic Teff cells while preserving Treg function, offering a potential therapeutic strategy for autoimmune diseases.
- Immunogen:
- CD6
- Molecular Weight:
- 44.2 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
