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Proteins and Peptides

Human CD46 Protein, Fc Tag (MALS verified)

Product Sizes
100 ug
£401.00
CD6-H5254-100UG
1 mg
£2679.00
CD6-H5254-1MG
About this Product
SKU:
CD6-H5254
Buffer:
PBS
Extra Details:
Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype.
Immunogen:
CD46
Molecular Weight:
40.8 kda
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human CD46 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human CD46 Protein, Fc Tag (Cat. No. CD6-H5254) at 1 ug/mL (100 uL/well) can bind FG-3246 (FOR46), Human IgG1 kappa with a linear range of 0.1-8 ng/mL (QC tested).