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Proteins and Peptides

Human Apolipoprotein H Protein, His Tag (MALS verified)

Product Sizes
100 ug
£318.00
APH-H52H3-100UG
1 mg
£2108.00
APH-H52H3-1MG
About this Product
SKU:
APH-H52H3
Buffer:
PBS
Extra Details:
Autoantibodies directed to negatively charged phospholipids, in particular cardiolipin, have been detected in the serum of patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). APS is characterised by venous and arterial thrombosis, recurrent spontaneous abortions and thrombocytopenia. It is now known that a serum cofactor, B Beta2-glycoprotein 1, is required for the binding of cardiolipin by autoantibodies in the sera of patients with APS. By contrast, anticardiolipin antibodies from patients with infectious diseases (in particular, syphilis) do not require this cofactor. B Beta2-Glycoprotein 1, also known as apolipoprotein H, is a relatively abundant serum protein (present at a concentration of about 0.2 mg/ml) that may play a role in coagulation. It has been shown to bind to platelets, mitochondria and negatively charged substances such as heparin, DNA, dextran sulphate and negatively charged phospholipids.
Immunogen:
Apolipoprotein H
Molecular Weight:
38.1 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human Apolipoprotein H Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human Apolipoprotein H Protein, His Tag (Cat. No. APH-H52H3) at 5 ug/mL (100 uL/well) can bind Biotinylated Human LDL R, His,Avitag (Cat. No. LDR-H82E7) with a linear range of 0.005-0.156 ug/mL (QC tested).