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Proteins and Peptides

Human Angiopoietin-like 3 / ANGPTL3 Protein, His Tag

Product Sizes
100 ug
£354.00
AN3-H52H3-100UG
1 mg
£2291.00
AN3-H52H3-1MG
About this Product
SKU:
AN3-H52H3
Additional Names:
ANG-5|Angiopoietin-5|ANGPT5|ANGPTL3|FHBL2
Buffer:
PBS, 0.05% CHAPS, pH7.4
Extra Details:
Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.
Immunogen:
Angiopoietin-like 3
Molecular Weight:
53.7 kda
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human Angiopoietin-like 3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human Angiopoietin-like 3, His Tag (Cat. No. AN3-H52H3) at 2 ug/mL (100 uL/well) can bind Monoclonal Anti-Human ANGPTL3 Antibody, Human IgG1 with a linear range of 0.5-2 ng/mL (QC tested).