Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)
Product Sizes
200 ug
£195.00
ALN-C52H5-200UG
1 mg
£719.00
ALN-C52H5-1MG
About this Product
- SKU:
- ALN-C52H5
- Additional Names:
- alpha-Synuclein|NACP|PARK1|SNCA
- Buffer:
- 100 mM NaAC, pH7.0
- Extra Details:
- Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
- Immunogen:
- Alpha-Synuclein
- Molecular Weight:
- 16.4 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
