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Proteins and Peptides

Human / Cynomolgus Activin RIIA / ACVR2A Protein, His Tag, low endotoxin (MALS & SPR verified)

Product Sizes
200 ug
£307.00
ACA-H5243-200UG
1 mg
£1154.00
ACA-H5243-1MG
About this Product
SKU:
ACA-H5243
Buffer:
PBS
Extra Details:
Activin receptor type-2A (ACVR2A) is also known as activin receptor type IIA, ACTR-IIA, ACTRIIA, and ACVR2, and is a single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily, the TKL Ser/Thr protein kinase family, and the TGFB receptor subfamily. Upon ligand binding, ACVR2A forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors, which then phosphorylate and activate SMAD transcriptional regulators. ACVR2A also serves as a receptor for activin A, activin B, and inhibin A (the latter in complex with betaglycan). Two type II activin receptors (ACVR2A and ACVR2B) have been identified, which bind different activins with distinct affinities.
Immunogen:
Activin RIIA
Molecular Weight:
15.4 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
Human / Cynomolgus Activin RIIA Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human / Cynomolgus Activin RIIA Protein, His Tag (Cat. No. ACA-H5243) at 1 ug/mL (100 uL/well) can bind Bimagrumab with a linear range of 0.05-1 ng/mL (Routinely tested).