Anti-Aquaporin 4 [rAb-53 (affinity matured)]
Product Sizes
1 mg
AB05080-10-0-BT-1MG
About this Product
- SKU:
- AB05080-10-0-BT
- Additional Names:
- AQP4; AQP-4; AQmab; aquaporumab; Aquaporin-4; MIWC; WCH4; Mercurial-insensitive water channel; rAb53; Aquaporumab; AQmabAM
- Application:
- Cell-based/Functional Assay, ELISA, Immunofluorescence
- Buffer:
- PBS
- translate.label.attr.clone:
- rAb-53 (affinity matured)
- Clonality:
- Recombinant Monoclonal
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- The original antibody rAb-53 was generated from the PCR products obtained from the human B cell clones isolated from CSF plasma of an neuromyelitis optica (NMO-IgG) seropositive patient using a dual vector transient transfection system. The affinity matured version was generated by using saturation mutagenesis.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds an extracellular conformation specific epitope on the human aquaporin 4 (AQP4), a water channel expressed on astrocytes throughout the CNS and in skeletal muscle and some epithelial cells outside of the CNS. It plays an important role in brain water homeostasis and in glymphatic solute transport. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the c
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab05080-10.0-BT
