Anti-CCL11 [CAT-213 (Bertilimumab; iCo-008)]
Product Sizes
1 mg
AB04187-10-0-BT-1MG
About this Product
- SKU:
- AB04187-10-0-BT
- Additional Names:
- SCYA11; Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11; 3G3
- Application:
- Block/Inhibit/Neutralise, ELISA
- Buffer:
- PBS
- translate.label.attr.clone:
- CAT-213 (Bertilimumab; iCo-008)
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This reformatted human antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- The original scFv antibody 3G3 was isolated from a human scFv phage display library after three rounds of panning against human eotaxin1. Optimization of 3G3 was conducted by heavy chain CDR3 randomization with point mutagenesis and light chain shuffling to obtain CAT-212 (scFv). Later on the sequence of CAT-212 was used to generate human IgG4 version of the antibody, which was called CAT-213.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds human eotaxin (CCL11). This CC chemokine directly promotes the accumulation of eosinophils in response to the presence of allergens, which is a prominent feature of allergic inflammatory reactions. It binds to CCR3.
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab04187-10.0-BT
