Anti-CD257 [I116A01 (Belimumab)]
Product Sizes
1 mg
AB04179-2-0-BT-1MG
About this Product
- SKU:
- AB04179-2-0-BT
- Additional Names:
- BAFF; BLyS; TNFSF13B; TALL-1; TNFSF20; ZTNF4; Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; B-cell-activating factor; Dendritic cell-derived TNF-like molecule; TNF and APOL-related leukocyte expressed ligand 1; LymphoStat-B; hBLySmAb-1.1; anti-BLyS-I116A01; PTA-3240; NSO-anti-BLyS-116A01-60
- Application:
- Block/Inhibit/Neutralise, ELISA, Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- I116A01 (Belimumab)
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Mouse
- Immunogen:
- The original antibody was isolate from a nonimmunized human scFv phage display library by 3 rounds of panning against human BLyS. Later on the human IgG1 version of the antibody was generated by separate cloning of heavy and light chain into expression vectors and transfection of mammalian cells like HEK293 or NSO to produce whole IgG.
- Isotype:
- IgG2a
- Purification:
- Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds human BAFF (BLyS) protein and inhibits binding of BLyS to its receptor. B-cell-activating factor (BAFF/CD257/BLyS) is a cytokine belonging to the tumor-necrosis factor (TNF) family. This cytokine binds to TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. BAFF is a survival factor for B cells that controls B-cell maturation. It is also involved in the stimulation of B- and T-
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab04179-2.0-BT
