Anti-GP38 [CC5-17]
Product Sizes
500 ug
AB04108-15-0-BT-500UG
About this Product
- SKU:
- AB04108-15-0-BT
- Additional Names:
- Glycoprotein 38; Crimean-Congo Hemorrhagic Fever Virus glycoprotein 38; CCHFV GP38; CC5_17
- Application:
- ELISA, Surface Plasmon Resonance
- Buffer:
- PBS
- translate.label.attr.clone:
- CC5-17
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- The original antibody was isolated from donor "CC5", a CCHFV survivor; circulating anti-GP38 antibodies were isolated from plasma using affinity chromatography. The paired heavy and light chain sequences were obtained from proteomics and genomics analyses, and the antibody was produced by transfecting Expi293 cells (expiCHO-S cells) with 1:1 ratio of heavy chain plasmid to light chain plasmid.
- Isotype:
- IgM
- Purification:
- Purified
- Reactivities:
- Virus
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody is specific for site I of CCHFV GP38 with three main determinants conferring binding; the first is LCDR3 which partially interacts with the N-terminus, the second interacts with A Alpha-helix 2 of GP38, and the third interaction is the HCDR3 which interacts with a larger hydrophobic pocket on top of GP38 and the large 20 AA flexible loop. This antibody binds to GP38 from CCHFV IbAr10
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab04108-15.0-BT
