Anti-Dxd [12G9-2]
Product Sizes
1 mg
AB04094-23-0-BT-1MG
About this Product
- SKU:
- AB04094-23-0-BT
- Additional Names:
- Exatecan derivative; Camptothecin analog
- Application:
- ELISA
- Buffer:
- PBS
- translate.label.attr.clone:
- 12G9-2
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Rabbit
- Immunogen:
- The original antibody was generated by immunizing BALB/c mice with Dxd-KLH conjugate.
- Isotype:
- IgG
- Purification:
- Purified
- Reactivities:
- Wide/Non-species Specific
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds Dxd, an anti-cancer alkaloid camptothecin analog, which is a potent DNA topoisomerase I (TOP1) inhibitor. By forming a stable ternary complex with TOP1 and DNA, it arrests the cell cycle to S phase, thereby preventing DNA replication and causing cell death. DxD is used for the generation of antibody-drug conjugates for targeted delivery of toxic materials to cancerous cells. A
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab04094-23.0-BT
