Anti-SN-38 [1H3-1]
Product Sizes
1 mg
AB04092-3-0-BT-1MG
About this Product
- SKU:
- AB04092-3-0-BT
- Additional Names:
- SN38; Topotecan; Camptothecin; CPT; 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin; 10-Hydroxy-7-ethylcamptothecin; 7-Ethyl-10-hydroxy-20(S)-camptothecin; 7-Ethyl-10-hydroxycamptothecin; NK 012; NK-012
- Application:
- ELISA, Surface Plasmon Resonance
- Buffer:
- PBS
- translate.label.attr.clone:
- 1H3-1
- Clonality:
- Recombinant Monoclonal
- Formulation:
- PBS only.
- Host:
- Mouse
- Immunogen:
- The original antibody was generated by immunizing BALB/c mice with SN38-BSA conjugate.
- Isotype:
- IgG2b
- Purification:
- Purified
- Reactivities:
- Wide/Non-species Specific
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds SN-38, which is an active metabolite of irinotecan (a semisynthetic analog of camptothecin - a topoisomerase I inhibitor) generated by carboxyl esterases through hydrolysis. SN-38 has potential antineoplastic activity. It binds and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replicatio
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab04092-3.0-BT
