Anti-IL-12p40 [Antibody 80]
Product Sizes
1 mg
AB03655-10-3-BT-1MG
About this Product
- SKU:
- AB03655-10-3-BT
- Additional Names:
- IL-12; IL-12B; IL-23; NKSF2; CLMF p40; Interleukin-12; Interleukin-23; Interleukin-12 subunit beta; IL-12 subunit p40; Interleukin-12 subunit p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; NK cell stimulatory factor chain 2; PMA204, Antibody 1; Antibody 50
- Application:
- Block/Inhibit/Neutralise, Cell-based/Functional Assay, ELISA
- Buffer:
- PBS
- translate.label.attr.clone:
- Antibody 80
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- The original mouse antibody PMA204 was generated by immunizing mice with recombinant human IL-12 as an immunogen. This antibody is the humanized version of the murine antibody PMA204 generated by grafting CDRs of the mouse antibody onto human framework regions. The antibody was further engineered by introducing backmutations and 3 point mutations in the heavy chain and using a combination approach to get the optimized variant.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody specifically binds an epitope between amino acid residues 253 and 286 of the common subunit p40 of the human IL-12 and IL-23. IL-12RB Beta1 binding to IL-12 and IL-23 is mediated via the common p40 subunit. IL-12 is a cytokine secreted by activated inflammatory cells (monocytes, macrophages, neutrophils, microglia, dendritic cells). IL-12 can act as a growth factor for activated T an
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab03655-10.3-BT
