Anti-Tissue factor [D3H44]
Product Sizes
1 mg
AB03461-10-29-BS-1MG
About this Product
- SKU:
- AB03461-10-29-BS
- Additional Names:
- CD142; TF; hTF; F3; Coagulation factor III; Thromboplastin; platelet tissue factor; factor III; D3
- Application:
- Block/Inhibit/Neutralise, Cell-based/Functional Assay, ELISA, Immunofluorescence, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- D3H44
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This reformatted human antibody was made using the variable domain sequences of the original Human Fab format for improved compatibility with existing reagents assays and techniques.
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- The original antibody was generated by grafting CDRs of parental murine antibody D3 onto human framework regions. Using computer graphics model of the murine D3 heavy and light chain sequences several amino acid residues in the CDRs as well as framework region of light and heavy chains were altered using site-directed mutagenesis in order to optimize antigen binding.
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds human tissue factor (TF) a hemostatic protein which is involved in the extrinsic pathway of coagulation. TF is receptor for circulating serine protease factor VIIa, activating the catalytic VIIa protease domain. The complex formed functions to activate the zymogen factor X into activated factor Xa, which then catalyzes the formation of Prothrombin to Thrombin. The pathways resu
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab03461-10.29-BS
