Anti-Glypican 3 [AB13E3]
Product Sizes
1 mg
AB03198-10-0-BT-1MG
About this Product
- SKU:
- AB03198-10-0-BT
- Additional Names:
- GPC3; Glypican-3; GPC-3; GTR2-2; MXR7; OCI5; DGSX; Intestinal protein OCI-5; GPC3#4; DWX-1
- Application:
- Cell-based/Functional Assay, ELISA
- Buffer:
- PBS
- translate.label.attr.clone:
- AB13E3
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- The parental mouse antibody GPC3#4 was generated by immunizing BALB/c mice with 50ug of purified human GPC-3 antigen emulsified in Freund's complete adjuvant. This original antibody was generated be grafting CDRs of the parental mouse antibody onto human framework region.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds human glypican 3 (GPC3).Glypican-3 is an oncofetal antigen that belongs to the glypican family of glycosyl-phosphatidylinositol-anchored heparin sulfate proteoglycans. It negatively regulates the hedgehog signaling pathway and positively regulates the canonical Wnt signaling pathway. Multiple studies have revealed that GPC-3 is overexpressed in hepatocellular carcinoma (HCC).
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab03198-10.0-BT
