Anti-TRKB [C2]
Product Sizes
200 ug
£463.00
AB03000-3-0-200UG
About this Product
- SKU:
- AB03000-3-0
- Additional Names:
- NTRK2; Trk-B; GP145-TrkB; TrkB tyrosine kinase; Tropomyosin-related kinase; BDNF/NT-3 growth factors receptor; Neurotrophic tyrosine kinase receptor type 2; Tropomyosin receptor kinase B; tyrosine receptor kinase B
- Application:
- Activate/Stimulate, Block/Inhibit/Neutralise, ELISA
- Buffer:
- PBS with 0.02% Proclin 300.
- translate.label.attr.clone:
- C2
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS with 0.02% Proclin 300.
- Host:
- Mouse
- Immunogen:
- The original antibody was generated by grafting of the murine antibody 38B8 CDRs onto human framework regions. The parental murine antibody 38B8 was generated by immunizing mice with human TRKB.
- Isotype:
- IgG2b
- Purification:
- Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds human TRKB and also cross reacts with mouse and rat TRKB. TRKB is a membrane bound receptor for brain-derived neurotrophic factor (BDNF). Upon neurotrophin binding it phosphorylates itself and members of the MAPK pathway. Signaling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders.
- Storage Conditions:
- 2-8[o]C Aliquot., -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab03000-3.0
