Anti-Desmoglein 3 [AK23]
Product Sizes
1 mg
AB02730-13-12-BT-1MG
About this Product
- SKU:
- AB02730-13-12-BT
- Additional Names:
- DSG3; PVA; CDHF6; Desmoglein-3; 130 kDa pemphigus vulgaris antigen; Cadherin family member 6
- Application:
- ELISA, Immunofluorescence, Immunoprecipitation
- Buffer:
- PBS
- translate.label.attr.clone:
- AK23
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- The original antibody was generated by immunizing Dsg3 knockout mice with recombinant mouse Dsg3-His in complete Freund's adjuvant subcutaneously.
- Isotype:
- IgG4
- Purification:
- Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds mouse Dsg3 and also shows reactivity for human Dsg3. It does not show any affinity towards Dsg1. AK23 recognizes a calcium-dependent conformational epitope on Dsg3, which consisted of the V3, K7, P8, and D59 Dsg3-specific residues that formed the adhesive interface between juxtaposed Dsg.
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab02730-13.12-BT
