Anti-PD-L1 [332M7]
Product Sizes
1 mg
AB02428-35-0-BT-1MG
About this Product
- SKU:
- AB02428-35-0-BT
- Additional Names:
- CD274; PDL1; B7-H1; B7H1; B7 homolog 1; hPD-L1; PDCD1L1; PDCD1LG1; PDCD1 ligand 1; Programmed cell death 1 ligand 1; Programmed death ligand 1
- Application:
- Block/Inhibit/Neutralise, Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- 332M7
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric rhesus antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Monkey
- Immunogen:
- The original parental antibody 332M1 was generated by immunizing BALB/c mice with recombinant human PD-L1. Later on the humanized version of 332M1 was generated (332M7) by grafting the CDRs of the original mouse antibody onto human framework regions.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Human, Mouse, Non-human Primate
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody strongly binds human and cynomolgus monkey PD-L1 and shows weak binding for mouse PD-L1. PD-L1 is highly expressed in many human tumors. . PD-L1 exerts an immune suppressive signal through binding to PD-1 and B7.1, and tumor expression of PD-L1 can mediate cancer immune evasion. Blocking this pathway, therefore provides a rationale for cancer immunotherapy.
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab02428-35.0-BT
