Anti-Notch 1 [N248A]
Product Sizes
200 ug
AB02406-23-0-200UG
About this Product
- SKU:
- AB02406-23-0
- Additional Names:
- Notch1; hN1; TAN-1; Neurogenic locus notch homolog protein 1; Translocation-associated notch protein TAN-1
- Application:
- Block/Inhibit/Neutralise, ELISA
- Buffer:
- PBS with 0.02% Proclin 300.
- translate.label.attr.clone:
- N248A
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS with 0.02% Proclin 300.
- Host:
- Rabbit
- Immunogen:
- The original antibody was generated by immunizing BALB/c mice with recombinant notch 1 fusion protein as immunogen. The fusion protein contained N-terminal leader peptide, EGF-like repeats 35 to 36, NRR (including Lin A, B and C domains and the HD domain) and a small portion of intracellular sequence.
- Isotype:
- IgG
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds to notch 1 at two distinct sets of epitopes, one in Lin-A domain and other in HD-C domain (aa 1705- 1710), causing the notch 1 to be locked down in the silent conformation, and thus preventing the receptor from being activated by its ligands.
- Storage Conditions:
- 2-8[o]C Aliquot., -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab02406-23.0
