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Antibodies

Anti-IL-6 [61H7]

Product Sizes
200 ug
AB02027-23-0-200UG
About this Product
SKU:
AB02027-23-0
Additional Names:
IL6; IFNB2; BSF-2; CDF; Interleukin-6; IL-6; B-cell stimulatory factor 2; CTL differentiation factor; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
Application:
ELISA
Buffer:
PBS with 0.02% Proclin 300.
Clone:
61H7
Clonality:
Recombinant Monoclonal
Extra Details:
This chimeric rabbit antibody was made using the variable domain sequences of the original Fab format, for improved compatibility with existing reagents, assays and techniques.
Formulation:
PBS with 0.02% Proclin 300.
Host:
Rabbit
Immunogen:
The original antibody was generated by immunizations of Llama glama with recombinant IL-6 followed by construction of phage display library, selection, screeing and purification.
Isotype:
IgG
Purification:
Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Specificity:
This antibody recognizes and binds interleukin-6 on the top of the four-helix bundle near the N and C termini. Here the VL domain sterically interferes with the C-terminal domain of IL-6R (residues 195-295). The overlap of the 61H7 epitope and the site I surface concentrates around a cavity occupied by both the HCDR3 loop of 61H7 and the IL-6R molecule.
Storage Conditions:
2-8[o]C Aliquot.
Type:
Antibody: Recombinant Antibodies