Anti-GITR [DTA-1]
Product Sizes
1 mg
AB01060-8-1-BT-1MG
About this Product
- SKU:
- AB01060-8-1-BT
- Additional Names:
- CD357; AITR; GITR-D; Glucocorticoid-induced TNFR-related protein; TNFRSF18; Tumor necrosis factor receptor superfamily member 18
- Application:
- Activate/Stimulate, Flow Cytometry, Immunoprecipitation, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- DTA-1
- Clonality:
- Recombinant Monoclonal
- Formulation:
- PBS only.
- Host:
- Rat
- Immunogen:
- This antibody was raised by immunising Wistar rats with the CD25+CD4+ T cell line. Hybridoma cells were generated by fusing spleen cells from the immunized rat with P3X63Ag8.653 myeloma cells, assessed for secreting antibodies capable of neutralizing in vitro CD25+CD4+ T cell-mediated suppression of anti-CD3-stimulated T cell proliferation9, and then cloned. This DTA-1 clone secreted a monoclonal rat immunoglobulin G2a (IgG2a) that showed high neutralizing activity.
- Isotype:
- IgG2b
- Purification:
- Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody is specific for murine GITR, a member of the tumor necrosis factor receptor (TNFR) family that is expressed at low levels on unstimulated T cells, B cells, and macrophages. Upon activation, CD4+ and CD8+ T cells up-regulate GITR expression, whereas immunoregulatory T cells constitutively express high levels of GITR.
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab01060-8.1-BT
