Anti-DR5 [YSd1]
Product Sizes
1 mg
AB00915-13-12-BT-1MG
About this Product
- SKU:
- AB00915-13-12-BT
- Additional Names:
- TRAILR2; Death receptor 5; DR-5; TRAIL receptor 2; Tumour necrosis factor receptor superfamily member 10B; TNFRSF10B
- Application:
- Block/Inhibit/Neutralise
- Buffer:
- PBS
- translate.label.attr.clone:
- YSd1
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- Fab fragments were generated by constructing phage-display libraries in which the CDRs of a humanised Fab framework derived from the murine Ab 4D5 were randomised (see Eigenbrot et al, 1993). The 1st and 2nd CDRs of the VH domain were replaced by randomised sequences consisting only of Tyr and Ser residues, whilst the 3rd VH CDR was substituted with random loops of variable lengths comprising all naturally occurring amino acids. Specific Fabs were isolated using ELISA screening.
- Isotype:
- IgG4
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- YSd1 was selected during phage display on the basis of its binding to the extracellular domain of DR5. It binds to the N-terminal portion of the molecule, binding to the smaller of two binding sites for the natural DR5 ligand Apo2L/TRAIL in the same fashion as the natural ligand.
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00915-13.12-BT
