Anti-Parathyroid Hormone-related Protein [HuMBC1]
Product Sizes
200 ug
AB00796-10-0-200UG
About this Product
- SKU:
- AB00796-10-0
- Additional Names:
- hu-q
- Application:
- Block/Inhibit/Neutralise, ELISA
- Buffer:
- PBS with 0.02% Proclin 300.
- translate.label.attr.clone:
- HuMBC1
- Clonality:
- Recombinant Monoclonal
- Formulation:
- PBS with 0.02% Proclin 300.
- Host:
- Human
- Immunogen:
- The anti-PTHrP antibody was prepared by immunizing mice with synthetic bovine thyroglobulin-conjugated PTHrP (aa 1-34) and generating the hybridoma cell line #23-57-137-1. The CRD regions of the variable region of the heavy chain was grafted onto the human framework regions of the human antibody S31679, and for the light chain FR1, FR2 and FR3 were grafted to that of HSU03868 and FR4 of the mouse antibody was grafted to that of S31679.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- HuMBC1 binds to human PTHrPat an epitope between residues 20 and 30(KD ~ 0.2 nM), a site closely overlapping with the GPCR parathyroid hormone receptor 1 (PTH1R) binding site. The antibody does not bind to PTH at concentrations of 10ug/ml. PTHrP is known to be a causative factor of humoural hypercalcemia of malignancy (HHM), which is frequently found at advanced stages of cancer. The protein binds
- Storage Conditions:
- 2-8[o]C Aliquot., -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00796-10.0
