Anti-Lymphotoxin alpha [3F12.2D3]
Product Sizes
200 ug
AB00788-10-0-200UG
About this Product
- SKU:
- AB00788-10-0
- Additional Names:
- LTA Alpha3 chimeric 3F12;LT;; LTA Alpha; Tumor necrosis factor beta; Tumor necrosis factor B Beta; Tumor necrosis factor-beta; tumor necrosis factor-B Beta; TNF beta; TNF-beta; TNF B Beta; TNF-B Beta; Lymphotoxin-alpha; Lymphotoxin alpha
- Application:
- Block/Inhibit/Neutralise, ELISA, Flow Cytometry, Surface Plasmon Resonance
- Buffer:
- PBS with 0.02% Proclin 300.
- translate.label.attr.clone:
- 3F12.2D3
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS with 0.02% Proclin 300.
- Host:
- Human
- Immunogen:
- 3F12 was prepared by hyperimmunizing BALB/c mice with purified recombinant human LTA Alpha expressed in E. coli - the hybridoma clone was selected for its ability to bind LTA Alpha3 by ELISA. The CDRs of the antibody were grafted to the framework regions of the mice mAb 2G7 to create the chimeric version of the antibody.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- 3F12 binds to human LTA Alpha3 and LTA AlphaB Beta (with a KD of ~0.3 nM, determined by BIACORE; ~ 37 pM, determined by ELISA) in both its soluble homotrimeric and membrane heterotrimeric forms. LTA Alpha belongs to the tumor necrosis factor (TNF) superfamily and is secreted as a homo-trimer (LTA Alpha3), or is expressed on the cell surface in complex with LTB Beta. Lymphotoxin is produced by lymp
- Storage Conditions:
- 2-8[o]C Aliquot., -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00788-10.0
